補體系統-藥物開發和臨床研究熱點

補體系統是由35種廣泛存在于血清、組織液和細胞膜具有酶活性的蛋白質組成的反應系統。補體激活有三種途徑：1)經典途徑2）旁路途徑3）凝集素反應/MBL途徑。補體系統可通過這3條既相對獨立又相互聯系的途徑被激活，從而發揮調理吞噬、裂解細胞、介導炎癥、免疫調節和清除免疫復合物等多種生物學效應，包括增強吞噬作用，增強吞噬細胞的趨化性；增加血管的通透性；中和病毒；細胞溶解作用；免疫反應的調節作用等。補體系統在抗感染和自身免疫及其他疾病的發展過程中發揮重要作用。

Euro Diagnostica補體功能檢測試劑盒優勢

1)ELISA檢測方法-三種激活途徑，相同的檢測程序。

2)2005年上市，穩定的檢測系統。

3）反映真實的體內補體水平。

4）3小時內出結果，快速、準確。

5）靈活性強-可以適應個性的化操作流程。

6）適合自動化檢測系統檢測（Dynex, DS2,DSX）

7) 與溶血試驗（CH50, APH50）檢測結果一致。

8）性能穩定，文獻引用廣

9）CE認證，可同時用于臨床和科研檢測。

Euro Diagnostica試劑盒應用實例:

1）藥物開發-補體靶向治療

研究表明,炎性疾病的發生、發展同補體的活化有關。因此,如何干擾和抑制補體活化產生的有害作用,成為藥理學研究的焦點之一，Euro Diagnostica試劑盒用于評估補體靶向治療效果（參考文獻4-8）。

2）臨床研究-補體功能/活性監測

補體功能的評估在補體相關疾病的發生和治療中具有重要意義。文獻5-9 用Euro Diagnostica試劑盒監測補體疾病治療中補體水平。

3）補體脫靶反應

在某些情況下，補體激活可引起嚴重反應，比如候選藥物的脫靶反應，抗體依賴的補體激活，移植排斥反應。（（參考文獻12-13）。）

訂購信息

應用文獻：

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